The Future of Pain Relief


How The AVACEN 100 Works

When the hand, enclosed in a special patented mitt, is placed inside the vacuum chamber, the microprocessor manages the application of negative pressure and heat to safely increase the temperature and volume of blood flowing through the high volume AVA’s. It is important to note that the application of heat without negative pressure is ineffective.


Infusing heat into the circulatory system reduces blood thickness (viscosity) and increases micro-circulation. Thinner blood facilitates more efficient flow through the skeletal muscles on its route to the smaller vasodilated capillaries (microvascular circulation) which the body uses to radiate the excess ATM produced heat into the cooler ambient air.

Micro-circulation Boost

An increase in micro-circulation enhances oxygen delivery and nutrition to the skeletal muscles while carrying away toxins. The result… healthier, more relaxed muscles throughout the entire body.

AVACEN 100 Summary

The AVACEN 100 is the answer for many people who need or prefer a cost-effective, easy to use, drug-free alternative for muscle relaxation to reduce pain which might be associated with a variety of acute medical conditions.

Users put their hand inside the AVACEN 100 vacuum chamber and rest it on a pad heated to about 108 degrees Fahrenheit for 10 – 30 minutes.

Over 4 Million treatments have been completed without adverse events.

Treatment can be comfortably self-administered in the privacy of the user’s home.

A single machine can be used by the entire family or multiple patients in a clinic.

Intended Use & Indications

U.S. FDA-Clearance: The AVACEN 100 is a non-invasive class II medical device that is cleared by the FDA as a heat therapy system indicated for the temporary relief of minor muscle and joint pain and stiffness; the temporary relief of joint pain associated with arthritis, muscle spasms, minor strains and sprains; muscular relaxation; and the temporary increase of local circulation where applied.

E.U. CE Mark Approval: A heat therapy system indicated for the temporary relief of minor muscle and joint pain and stiffness; the temporary relief of joint pain associated with arthritis, muscle spasms, minor strains and sprains; the temporary relief of widespread pain associated with fibromyalgia; muscular relaxation; and the temporary increase of micro-circulation.



The word arthritis literally means joint inflammation “arthr” stands for joint and “itis” stands for inflammation.

Arthritis is a common disease of joints pain which is not well understood. Rather, Arthritis is not a single disease, it’s a disorder that affects our body joints. The pain of Arthritis most often affects areas in or around joints. Joints (body parts) where bones meet such as your knee, elbow, wrist, ankle, hands, fingers, etc. There are 100 plus different types of arthritis problems or diseases. As stated above it affects joints such as muscles, tendons and other parts of the body parts like skin and internal organs.

In other words we can say Arthritis is a group of conditions involving inflammation of various body parts. Most commonly it’s the joints that are inflamed, but not exclusively. It also affects skin, eyes, bowels or virtually any other part of the body. With the inflammation there may be damage, particularly with the joints.

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Capillary Micro circulation

The main functions of the micro circulation are the delivery of oxygen and nutrients and the removal of carbon dioxide (CO2). It also serves to regulate blood flow and tissue perfusion thereby affecting blood pressure and responses to inflammation which can include edema (swelling).

The blood capillaries are where the important functions of the micro circulation take place: the exchange of material between circulation and cells. Capillaries are the smallest of the body’s blood vessels. They are only one cell thick, and they are the sites of the transfer of oxygen and other nutrients from the bloodstream to other tissues in the body; they also collect carbon dioxide waste materials and fluids for return to the veins.

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Hyperthermia holds great promise to advance immunotherapy in the treatment of cancer. Multiple trials have demonstrated benefit with the addition of hyperthermia to radiation or chemotherapy in the treatment of wide-ranging malignancies. Similarly, pre-clinical studies have demonstrated the ability of hyperthermia to enhance each of the 8 steps in the cancer-immunotherapy cycle including stimulation of tumor-specific immunity. While there has been an extensive recent focus on augmenting immunotherapy with radiation, surprisingly to date, there have been no clinical trials assessing the combination of hyperthermia with immunotherapy. The study of hyperthermia with immunotherapy is particularly compelling when considered in the context of a new treatment paradigm for this anti-neoplastic modality. Novel concepts include ease of treatment including elicitation of the tumor-specific response of not requiring whole tumor heating, potentially shorter treatment time, better treatment tolerance as opposed to other multi-agent approaches to immunotherapy and the ability to apply heat repeatedly with immunotherapies, unlike ionizing radiation. Several questions remained with regard to clinical integration which can be readily addressed with thoughtful clinical trial design building upon lessons learned at the bench and from clinical trials combining radiation and immunotherapy. Examples of promising avenues for clinical investigation of hyperthermia and immunotherapy including melanoma, bladder, and head and neck cancers are reviewed. In summary, there is a present convergence of factors in oncology that compel further investigation of the integration of hyperthermia with immunotherapy for the benefit of cancer patients.

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The Future of Pain Relief

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